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In combination with antipsychotics these risk factors can put patients at an even greater risk of cardiac events and sudden death.
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Treatment should be initiated with losartan potassium 50 mg once daily.
Losartan is an angiotensin II receptor antagonist.
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Losartan and other angiotensin-receptor antagonists exhibit fetal toxicity and should be avoided during pregnancy, particularly in the second and third trimesters.
The most parsimonious explanation is that the positive studies are false positives.
While 90 percent of the treated rats survived, 14 percent of those in an untreated control group did not.
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Angiotensin II receptor blockers (ARBs) are the newest class of approved antihypertensive agents and the second class of drugs to exert their primary antihypertensive action by interrupting the renin-angiotensin system.
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