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No imaging technology can give a definitive diagnosis, however NICE recommend the use of magnetic resonance imaging (MRI) for investigating the cause of parkinsonism, and single photon emission computed tomography (SPECT) to distinguish essential from parkinsonian tremor.

Patients who have an existing diagnosis of schizophrenia and require regular monitoring of medical status.

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Many of the remaining 25 percent suffer from a serious underlying brain disease that cannot be relieved through anticonvulsant therapy; others continue to have seizures because they refuse prescribed medication, they use it incorrectly, or their bodies do not reliably absorb the drugs.

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The effects of gabapentin, which was initially thought to have GABAergic effects, were compared with those of baclofen in a double-masked study including patients with APN.

Although mood symptoms and episodes must be present for a substantial portion of the total course of the illness, a diagnosis of schizoaffective disorder also requires that psychotic symptoms, such as delusions or hallucinations, have been present for a minimum of 2 weeks in the absence of an active mood disturbance.

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Several diseases, including MSA, CBD, and PSP, are sometimes referred to as "Parkinson's-plus" diseases because they have the symptoms of PD plus additional features.

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Recent studies support the earlier observations that motor fluctuations are part of the natural course of Parkinson's disease and are probably related to postsynaptic alterations in the striatum.

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In addition to a possible link to schizophrenia itself, many antipsychotic medications can raise blood sugar levels.

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Olanow, CW, Watts RL, Koller WC: An algorithm (decision tree) for the management of Parkinson's disease: treatment guidelines.

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Severe side effects, including respiratory arrest, very low blood pressure, and loss of consciousness, have been reported in a few people taking anti-anxiety medication and clozapine.

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Risk factors for increased dystonia in patients with include long disease duration and use of medication.

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