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These studies have uniformly demonstrated that initiating ACE-I therapy prior to the onset of congestive heart failure (pulmonary edema or ascites) does not delay the onset of clinical signs, and does not prolong survival.
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In the meta-analysis of 76 studies, 14 studies reported dose timing, and once-daily dosing increased the rate of dose-timing compliance compared with multiple daily dosing (74% versus 58% for twice daily, 46% for 3 times daily, and 40% for 4 times daily).
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Had all medications been discontinued when he first developed jaundice, the role of enalapril versus simvastatin (or fenofibrate) would have been difficult to define.
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Decreases of similar magnitude in systemic vascular resistance were noted in previous studies with enalapril alone or with enalapril and placebo.
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Increase in bradykinin stimulates production of vasodilating prostaglandins.
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To evaluate the influence of the angiotensin-converting-enzyme inhibitor enalapril (2.
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Although enalapril maleate was antihypertensive in all races studied, black hypertensive patients (usually a low-renin hypertensive population) had a smaller average response to enalapril monotherapy than non-black patients.
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